Not here. I've been playing Ghostwire: Tokyo for a while now thanks to the Epic giveaway. The only issue I had was when I was setting up the wine prefix and the Denuvo DRM decided that I had installed the game enough times for today!
I have been using TW (and its predecessors) for around 17 years and have no major complaints at all! KDE Plasma is my preferred desktop and TW comes with that option as a default. Wayland is available but still has a few niggles with KDE Plasma in my experience.
TW will play both indie and mainstream games with no problem and comes with many repos of up-to-date packages. CoolerControl is a good app for setting up your Kraken if necessary. Your GPU should work out-of-the-box.
TW supports Secure Boot and should detect it when setting up. My advice for installation is to create a bootable USB stick with the network install version of TW and go from there. The GUI allows you to select a default installation or set things up just how you like them.
Compiled it on my OpenSUSE Tumbleweed system last week. As with the author of the Ubuntu article: I'm rubbish at the game but it compiled and executed just fine!
Yes, the first part of the config file reads as follows: "{"account_tracker_service_last_update":"13334489856807897","alternate_error_pages":{"backup":true},"announcement_notification_service_first_run_time":"13334506503682677","autocomplete":{"retention_policy_last_version":108},"browser":{"has_seen_welcome_page":false,"window_placement_popup":{"bottom":429,"fullscreen":false,"left":4,"maximized":false,"right":696,"top":28,"work_area_bottom":1170,"work_area_left":0,"work_area_right":1920,"work_area_top":0}},"
I've tried changing the window size fields to other values but this seems to make absolutely no difference at all. Alt+Enter has the same effect as I have previously described.
The game appears to be programmed using javascript.
My wife actually loves playing KPatience! I've tried to get her on to slightly more meaty games but sometimes it's the simple ones that win people over :-)
The best place to ask is Linux Crack Support.