jet @ jet @hackertalks.com

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2 yr. ago

Freetube does this really well

Reduce sources of systemic inflammation, improve immune function.

Take metabolic health seriously, see sugar as the drug it is, industrial oils are a huge health iceberg.

normal human things like consuming things in excess.

Excess and normal are contradicting each other in this sentence.

Yes cellular metabolism can use glucose, but that glucose in humans does not need to be eaten in the form of carbohydrates, the body is perfectly able to make its own glucose via gluconeogenesis

Fats need to be balanced.

What does this mean?

Vitamin C is also lacking in an all meat diet devoid of organ meats.

Vitamin C is in meat in small amounts, but if one is eating only meat then there is not glut4 competition and that vitamin c is very effective.

Addictions are real things in both my experience and reading - can you explain how they are not real?

Carbohydrates are not necessary for human nutrition, so there is no such thing as a carbohydrate imbalance.

Eating saturated fat does not become bad at any level of consumption.

Meat has everything we need in it, its the perfect food.

This is my shelf, there are many like it but this one is mine...

Max headroom would like to have a word.

Things humans can do that ai can't, currently do, politicking, sleeping to the top, building a brand outside of work, demonstrating integrity

I've enjoyed reading this discussion. I would like to contribute that the most significant factor in excessive obesity isn't a typically a nutrient deficiency, or even a moral failing in CICO - it's carbohydrate addiction.

Yes, hunger can be driven by low-levels of essential nutrition, pica during pregnancy is a great example of that. Many people are over-fed and under-nourished, so when they get hungry they continue to go to their deficient food source (probably something carbohydrate heavy).

What I’m looking for basically is just evidence for the claim posted above us, specifically that “it is a fact that weight loss results in lifelong ravenous hunger due to fat cell signaling”

In my reading the the literature there is nothing to support this "fat cells make you hungry" theory.

At best there is an association between fat people and fat cell population, but given hyperplasia is more common in people of european descent its not a causal connection. Plus this theory doesn't account for fat people from hypertrophic populations (asians).

empty/depleted fat cells basically scream “we are hungry”, so as soon as you get off Ozempic, you basically can’t stop eating until you regained at least the former state.

I don't think that is quite right. If people on Ozempic use the opportunity to adapt to a low carbohydrate diet, when they come off the drugs they won't be suffering from the save sugar craving addiction cycle.

Fat cells don't scream "we are hungry" they scream "we are full" that is what leptin signaling is for, but carbohydrate addiction is a much stronger signal for many people.

Essentially PCOS causes a craving for carbs and sugar

There is a good amount of literature documenting PCOS being a downstream effect of metabolic syndrome. Metabolic syndrome is caused by carbs and sugar. The addiction and cravings are real, but the order is reversed.

You might want to consider keto or low carb. It will help with your blood sugar.

I worry about that soldering iron technique

The most amazing piece of technology from the hit arthouse game stray was the ability for a third person camera floating behind a cat to never have its asshole in view.

I know this is a political post, but I'm going to respond to the longevity part

Telomeres in the human genome would indicate the maximal lifespan of about 120 years.

I don't think it's normal for humans to become diminished as they age. Dementia, Alzheimer's, type 2 diabetes, these are not historic problems. These are new plagues of prosperity that we're dealing with in the modern context.

Something with our industrial food system, or our medical system, or are farming system... Is making old age less graceful then it could be.

My new life goal: live long, die fast.

Watch Spokane Police arrest two vegan protesters outside a restaurant during a heated demonstration on March 6th 2025. Officers charge them with disorderly conduct, referencing a prior restaurant disruption. The activists argue they were peacefully protesting animal abuse and accuse the police of siding with cruelty.

Heated is a bit of a stretch looks like the street was empty, they were shouting at diners through the restaurant windows.

That's the big difference between being unreasonable at people online vs in real life.

Normal people minding their own business just want to be left alone, and they will leave you alone. You break that social contract and things happen.

Online people make a real tempest in a teacup about small things, and due to algorithmic the echo chambers builds.

My experiences on Lemmy almost never match how people act in my real life.

That is a great point! there is debate about our diagnostic capabilities improving. However, pick a year, any year and use that as year zero. We still have to account for the geometric growth of cancer after that year.

Going back to pre-1900s cancer, it was seen on rare occasions, if it was as common as today (50% of westerners will have cancer in their lives) then it would have shown up with some frequency in the historical medical literature.

I would use the same thought experiment for type 2 diabetes, cardio vascular disease (someone would have made a record of otherwise healthy people just falling over dead randomly in the streets), etc.... the modern chronic diseases all appear to have a common starting point in the historical record >1900, which suggests a common cause. I think metabolic health is the most likely unifying theory, I could be wrong, but improving metabolic health doesn't hurt.

We know there is a 3x risk of cancer for people with obesity. We know there is a 3x risk of cancer for people with type 2 diabetes. We also know global obesity is going up, and type 2 diabetes is going up. There are almost 1 billion people in the world diagnosed with T2D. The country with the highest T2D rate is also the country that eats the least amount of meat (India). Some new thing has happened globally since 1900 to cause this change.

This is exactly why I love the internet

Spell checker in my web browser!

Health effects associated with consumption of processed meat, sugar-sweetened beverages and trans fatty acids: a Burden of Proof study

Study title... CNN title is only about meat.

A meta-analysis of observational epidemiology

All of the issues with epidemiology apply

• association is not causation
• hypothesis generating only
• healthy user confounders
• people eating meat are often eating high carbohydrate diets
• metabolic context of the participants
• food frequency questionnaires filled out yearly or every 4 years.

I don't have access to the paper, it hasn't made it to the Free Academic circles yet, so I haven't been able to read it.

Is everything we eat associated with cancer? A systematic cookbook review

I personally think the reason EVERYTHING is linked to cancer, as well as the massive surge in cancer since the 1900s, is all due to the modern metabolism (sugar burners) being very different then pre-1900 metabolism (fat burners)

• High carbohydrate load, high blood glucose load, high insulin levels
• Industrial Oil, systemic body inflammation
• Agrochemical contamination of food supply, more systematic inflammation

The problem with these observational studies is they don't look at the modern metabolic context, so in this context, yes EVERYTHING is associated with cancer - because the studies arn't looking at the right variables.

This is exactly why hard science doesn't use association to draw conclusions, epidemiology is hypothesis generating only

If you haven't read about the Metabolic Theory of Cancer I highly recommend giving it a read. It's a much more compelling model, and explains the surge of cancer since 1900, as well as actionable steps to reduce incidence (reduce sugar and inflammation).