The difference with Pop OS in particular is that they offer installation ISOs with the proprietary NVIDIA drivers preinstalled, meaning you don't have to fuss with installing them at all.
IoT is supported until January 2032, while standard LTSC is only supported until January 2027, which only, like, an extra year or so of support over regular Windows 10. I've never heard anything about IoT being less secure but I'm far from being an expert lol.
GrapheneOS has been basically flawless for me, most of the time I forget I'm even using a custom rom. Using the Aurora Store, along with a few select apps in a work profile with sandboxed Google Play services goes a long way in terms of plugging the usability gap. I know there's supposed to be issues with banks, but at least in my anecdotal experience, I've used accounts from 3 different banks and haven't had any issues.
NVIDIA's Debian repo for Cuda has more up to date GPU drivers, if you don't wanna manually install from the .run file. Documentation here, its not reflected yet in the docs but there's a Debian 12 repo.
In my experience Arch is pretty unstable, though. I've never had an Arch installation that didnt break by the end of the month. Flatpaks allow me to use a stable base like Debian while having certain programs more up to date.
LibRedirect works for not only redirecting YouTube to Invidious (or Piped if you prefer) but also for alternative front ends for other services, like Nitter for Twitter.
The difference with Pop OS in particular is that they offer installation ISOs with the proprietary NVIDIA drivers preinstalled, meaning you don't have to fuss with installing them at all.