✨🫐🌷🌱🌌🌠🌌🌿🪻🥭✨ @ allo @sh.itjust.works

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Also i havent researched the validity of the ivf not allowed in china stuff, but I don't consider it a bad thing He giving the parents an avenue to a hivfree child when they otherwise are assumed 'too poor' to be able to do it. In fact that totally matches his statements about cures should not be paywalled; and i agree with him. Good thing for the families he was doing this experiment. Now they can have an hiv free child where they couldn't before.

that is also where i place the importance: on the kids and parents. Not the science community nor science councils. Probably why i dont work at a university lab

and those arent even the most aggressive articles. Anyway, for people reading, there are many contradictory parts of He's case depending where you look.

thanks i agree i had the 'kids would have been born with hiv otherwise with no alternative' part wrong. good correction. I have edited my comment accordingly. He removed the Hiv with one procedure and immunized with the other.

heres a much less biased telling of events. No it doesnt 100% support He being a saint. it isnt that biased nontrustable trash tho "As the couples listened and flipped through the forms, occasionally asking questions, two witnesses—one American, the other Chinese—observed. Another lab member shot video, which Science has seen, of part of the 50-minute meeting. He had recruited those couples because the husbands were living with HIV infections kept under control by antiviral drugs. The IVF procedure would use a reliable process called sperm washing to remove the virus before insemination, so father-to-child transmission was not a concern. Rather, He sought couples who had endured HIV-related stigma and discrimination and wanted to spare their children that fate by dramatically reducing their risk of ever becoming infected.

He, who for much of his brief career had specialized in sequencing DNA, offered a potential solution: CRISPR, the genome-editing tool that was revolutionizing biology, could alter a gene in IVF embryos to cripple production of an immune cell surface protein, CCR5, that HIV uses to establish an infection. "This technique may be able to produce an IVF baby naturally immunized against AIDS," one consent form read."

funny how things can look so different according to what side u are on. tho im not even going for pro He articles, just neutral or interviews. As far as your hostile ones where they weaponize anything they can... (reminds me of politics) the part I find sillyest is when they complain how He only successfully did the full mutation to one girl so the other may not be immunized. Like it's bad he did it but also bad he didnt do it enough. lol. its exactly like politics.

I applaud how nearly every time he opens his mouth it is something caring about the wellbeing of others and his goals are noble. Where I am critical of He is that he seems to be such an idealist that when he cures these big diseases he assumes the next step is to roll out the cure to all people of the world. I love how he is against the 'charge 2million per cure' mentality and thinks cures should be available to all, but imo the risk level of doing a genetic change to the entire population is unacceptable. A single wrong unforseen thing and its like zombie apocalypse. I see from his personality why he rushed ahead and did the Lulu Nana antiHIV thing. Personally I think he should be spearheading embryo science and doing his stuff since his heart is good, but watched over so he doesnt go too far. Let him go farther than anyone else, beyond lulu nana, but watch him carefully so no zombie apocalypse.

HJK: Many years ago, my mother was diagnosed with Alzheimer’s disease, and unfortunately, there are no medicines available to cure it. There are many more people who are suffering from diseases that do not have a cure, so I want to do something to change it.

CT: Can you tell us about the research that you led around Lulu and Nana that was publicized in 2018? It’s been almost six years since this research was shared with the world, how are they doing now?

HJK: Lulu and Nana’s parents are HIV infected patients and they want to have a baby, a healthy baby, a baby that is not worried about HIV any more. So we took the sperm and egg from their parents during the IVF procedure, using a tiny syringe needle to inject the gene editing formula to the fertilized egg, to change one gene, and closed the door that HIV virus used to enter human cell. We then transfer the fertilized egg from the peri dish back to their mother’s uterus, and after several months, Lulu and Nana were born. Lulu and Nana are five years old now and they are healthy and happy just like any other kids in the kindergarten. I am glad that I have helped two families using my science knowledge.

CT: How did you balance the need for progressive gene editing research with ethics and general public perception?

HJK: Science research must be transparent and open, and should be approved by an ethics committee composed of medical doctors, lawyers, patient representatives, and local resident representatives.

CT: Last month, the FDA approved a new CRISPR gene editing treatment, Casgevy, by Vertex Pharmaceuticals and CRISPR Therapeutics, for sickle cell disease. To give context to the audience, sickle-cell is caused by inheriting two bad copies of one of the genes that make hemoglobin. On top of severe symptoms, life expectancy with the disease is just 53 years and it affects 1 in 4,000 people in the US. However, sources are reporting the gene editing treatment price will be $2-3m USD per patient. First, can you tell us your thoughts on this FDA approval milestone and what it means for gene-editing based medicines? And second, do you see a future where the prices for gene therapies will be lowered, making them more accessible to patients?

HJK: The approval of Casgevy is a great success for science, but not for patients. It cost more than 2 million dollars, and few patients will be able to afford it. This drug also has significant side effects including infertility.

CT: Gene therapies aside, what are your thoughts on the current state of affairs of genomics-based reproductive technologies, such as embryo gene sequencing? How do you foresee reproductive technologies being transformed by genomics in the future?

HJK: Embryo gene sequencing such as PGT-P is not ready for clinic application. Many diseases such as diabetes are influenced by hundreds of genes, and we do not have solid science to determine the risk of diabetes by genomic information.

CT:I see. So you think it's still a little bit early for clinic use.

HJK: Yes.

CT: What are your aspirations for the next chapter of your scientific career?

HJK: I believe embryo gene editing can help us to defeat many diseases and improve human health. I have proposed a research project, using embryo gene editing to help prevent Alzheimer’s disease, so our next generation will no longer worry about Alzheimer’s. I am going to do it slowly and cautiously, make sure we comply with all local laws and the international ethics guidelines. We are going to do it in a mouse first and we have no plan to move on to human trials. At every step, we will disclose our progress in full to the whole world and post it in my personal social account on Twitter.

CT: Why focus on Alzheimer's?

HJK: As I said, my mother has Alzheimer's. So personally, I also have some high risk for Alzheimer's when I get old, and maybe my daughters are at risk of having it in the future too, and Alzheimer's has no cure. If this project is successful, perhaps Alzheimer’s disease can be completely eliminated from future generations.

CT: Wow. That would be very powerful if it’s successful – to be able to get rid of a disease in future generations. I have another question. If you could go back in time to 2018, would you have done anything differently?

HJK: I did it too quickly. One thing I did not finish is the health insurance. In the informed consent document we signed with the parents of Lulu and Nana, we agreed to buy additional health insurance for Lulu and Nana. However, after the birth of Lulu and Nana, due to too much negative media attention, no health insurance company wanted to get involved. Now, as an alternative, I am planning to set up a charity foundation in Singapore to raise money to cover any future medical expenses of Lulu and Nana.

CT: Let me know if you have a link to donations for the charity. I'd be happy to share it with interested individuals.

HJK: Thank you. That'd be great.

CT: What are some valuable lessons that you learned over the last few years that you can share with the viewers?

HJK: In the past few years, my wife and daughters were living in a hard time. In the future, I won’t let my family get into the same situation again.

CT: I'm sorry to hear that about your family. Thank you so much for answering all of my questions, Dr. He.

HJK: Thank you.

and imagine if we had 5 more hands; we could make 5 more points.

#thefuture

Just so you all know what his horrible crime was...

"Formally presenting the story at the Second International Summit on Human Genome Editing at the University of Hong Kong (HKU) three days later, he said that the twins were born from genetically modified embryos that were made resistant to M-tropic strains of HIV.[48] His team recruited 8 couples consisting each of HIV-positive father and HIV-negative mother through Beijing-based HIV volunteer group called Baihualin China League. During in vitro fertilization, the sperms were cleansed of HIV. Using CRISPR/Cas9 gene-editing, they introduced a natural mutation CCR5-Δ32 in gene called CCR5, which would confer resistance to M-tropic HIV infection."

So imagine a couple where one has HIV but they really want to have a baby. He basically made it so their children were hiv free and then immunized them (edited for accuracy). In all my Crispr research, this is the story that most caused me to feel the science system had wronged a good person. Literally Lulu and Nana can grow up healthy now. Science community smashed him, but to the real people he helped he is basically a saint. I love now seeing him again and seeing he still has his ideals. Again, fuck all those science boards and councils that attacked him. Think of the actual real couple that just wants a kid without their liferuining disease. Also I love how he isnt some rightwing nutjob nor greedy capitalist. See his statement about this tech should be free for all people and he will never privately help billionaires etc etc.

anyway, ideals. i recognized them when i first came across him; i recognize them now. I know enough about him that I will savagely defend this guy. He isn't making plagues or whatever. He is helping real people.

my type of guy. And he still does his research to help people even with the public treating him like it does.

I'd like to get in to genetic engineering. When I came across his story while researching crispr, I sympathized with him. He did the experiment in what to me is a moral way. Just going on memory it was like 'take 4 embryos, edit two, keep parents in the loop and ask which embryo they want'. Complain all you want, but he did no wrong; it's the public and system that then wronged him. So yeah, of nearly anyone, he is the one who most gets to say 'ethics ruining science'. It's ironic because there are tons and tons of unethical science activities done literally every day. But for those to be ignored and instead ethics police to hit him when he did all his stuff morally and resulted probably in two extrahealthy kids... Yeah I agree with him. I think everything should be done morally, but if he is going to be hit like that under the guise of 'ethics' then nah. 'ethics' needs to be replaced by morals and decency. Literally horrifically murdering people (war) is legal and accepted while him using science, AND CORRECTLY, to protect people from liferuining diseases got the treatment it did? nah. I hope he continues growing and doing more genetic engineering and this time doesn't share a single thing with the public. He should never give the people that treated him like that a single piece of data. There are ways to bypass the patent thickets if he isn't selling what he does, especially if he shares no info about it. I support him.

prepares for 200 downvotes

im trying to do this :)

no meat or dairy seems much much healthier than trying to deal with inflammation

will try again starting tonight thank you

tru. most of the ones mentioned here ive never seen anything negative about (tho havent checked all their mod logs). yeah maybe to say 'best' is less accurate than 'among the handful that are the best' (or mouthful if one has no hands)

ty

i am not sure what chuffing noise you are talking about.

I know pits and shortsnout breeds do different vocalizations than my longsnout dogs.

The signs my dogs make that dont involve tongue or tail for similar emotions are:

• the butt up chest down stretch
• the aforementioned shake
• deep breath
• an mhm breath which can be nuanced to mhmhmhmhm occasionally

i know the first three have an aspect of innateness because i have seen disconnected dogs do the same for the same sort of experience. I am unsure of the mhm because i have not seen dogs outside my own culture of dogs do it so it may be cultural. They may or may not idk. Don't know the chuffing tho

because it just is and anyone who believes anything different from what i believe is wrong

true. of course im only speaking of my own dogs and those i've met. if not removing water or dirt from coat, it is done when: a friend comes by, after getting a treat, sometimes if they know a treat is coming, a song they like plays, someone treats them nicely, they just had a good experience, they like what i or someone else does, they are reassuring after a scuffle or something questionable that 'everything is fine'... I agree it isn't exactly a yes. It definitely feels closer to a yes than a no tho. I would say it isnt a Yes so much as a confirmation of good.

thanks. secretly that's what i thought :)

i always appreciate your comments

Looks like someone hasnt been following current events :)

makes sense. So it is partly BECAUSE the people are accused of gang and hezbolah affiliation that it is extra controversial instead of being less controversial; with the reason being lack of evidence and fair trial, and that that shouldnt even start to be ok

personally im surprised the trump administration is even giving reasons for deporting people