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InitialsDiceBearhttps://github.com/dicebear/dicebearhttps://creativecommons.org/publicdomain/zero/1.0/„Initials” (https://github.com/dicebear/dicebear) by „DiceBear”, licensed under „CC0 1.0” (https://creativecommons.org/publicdomain/zero/1.0/)FR
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2 yr. ago

  • The linked article has a dedicated section «1.3.6 Key truth #6: ‘There’s hope’».

    I believe you are wrong because you are inconsiderate to the OP and to the other readers, by commenting before reading the linked article.

    I believe you are wrong because you moan before doing your (very small and straight foward) part.

  • After sparing this paper a fair bit of attention I feel I've wasted it.

    Nowhere in the paper could i find in what conditions the test samples were kept during the experiment. This is pretty basic stuff. At this stage I'd wage sloshing was the issue.

    Reading this part of the methodology:

    "2.2 Initial sperm analysis

    After liquefaction...

    [Two paragraphs later, in the same section: ] After this first analysis, the 15 sperm samples were split into two fractions. All the samples were exposed to 'Parabolic flight' (split 1) and to..."

    Did they liquefied the samples and tested like that? Whaa?

    The "After this first analysis" should not be in the "2.2 Initial sperm analysis". It just shouldn't!

    Then I think "15 sperm samples were split into two fractions". ... "the samples were exposed to 'Parabolic flight' (split 1)" --- splits, fractions, what a mess!! At this stage I've wasted enough.

    The paper should be retracted, the reviewers spanked and the editor fired.

  • Abstract

    Most of the widely used vaginal lubricants in the U.S. and Europe are strongly hyperosmolal, formulated with high concentrations of glycerol, propylene glycol, polyquaternary compounds or other ingredients that make these lubricants 4 to 30 times the osmolality of healthy vaginal fluid. Hyperosmolal formulations have been shown to cause marked toxicity to human colorectal epithelia in vivo, and significantly increase vaginal transmission of genital herpes infections in the mouse/HSV model. They also cause toxicity to explants of vaginal epithelia, to cultured vaginal epithelial cells, and increase susceptibility to HIV in target cells in cell cultures. Here, we report that the osmolality of healthy vaginal fluid is 370 ± 40 mOsm/Kg in women with Nugent scores 0–3, and that a well-characterized three-dimensional human vaginal epithelium tissue model demonstrated that vaginal lubricants with osmolality greater than 4 times that of vaginal fluid (>1500 mOsm/Kg) markedly reduce epithelial barrier properties and showed damage in tissue structure. Four out of four such lubricants caused disruption in the parabasal and basal layers of cells as observed by histological analysis and reduced barrier integrity as measured by trans-epithelial electrical resistance (TEER). No epithelial damage to these layers was observed for hypo- and iso-osmolal lubricants with osmolality of <400 mOsm/Kg. The results confirm extensive reports of safety concerns of hyperosmolal lubricants and suggest the usefulness of reconstructed in vitro vaginal tissue models for assessing safety of lubricants in the absence of direct clinical tests in humans.

  • “Who would have known that the mighty people of Yemen would challenge the empires of the world,” he added, referring to the Houthi attacks on international shipping in the Red Sea that have led to two nights of retaliatory strikes by the US and UK.

    This does not sound like somebody interested in promoting peace.

  • Keeping things sterile is very labour and energy intensive, even in the Pharma industry, where the profit margins are orders of magnitude above what you can do in the food industry.

    Look this will sound harsh, but it's not, really.

    Your reasoning is good if you compare it to an hypothesis a student of Pasteur or Koch could have thought of 150 yrs ago.

    Thus I have to ask you, why did you think you have a good take on this?

  • /doubt

    Could the solution to the decades-long battle against malaria be as simple as soap?

    No. And not simple.

    What a terrible choice of title.

    If adding hand-wash dish soap works with a family of insecticides but not with another one, it's not simple. And it's not just the soap. Also the 'new' insecticides, neocotinoids, are quite problematic on their own, which also makes them not simple to use.

  • You say it broke relatively recently, so likely only one thing has failed. That seems to be the o-ring. As others have said, that is easily replaceable.

    But ...

    I think you haven't included all the parts in the photo. Or is that just it?

    What is the status of the funnel where you place the ground coffee?

    Also, how does the side safety valve look like? It should be on the side of the bottom compartment. The moka works with vapour pressure. A good valve is needed.

    As others said, NO dishwasher. And I would also avoid much scrubbing. The moka is made out of aluminum which is a soft metal, easily damaged by acids, and with harsh scrubbing.

  • Hmmm..

    I think I can see where that took you.

    On this subject, the shallowness of your thoughts is only matched by the authoritative way in which you express them.

    Can I suggest you to allow yourself to be left your thoughts to think it over.