I've used it to encrypt both Pi4's and 5's. I think it's most compatible with Raspberry Pi OS (Bookworm), used it on both Lite and Desktop editions. Remember to use non-AES encryption since only the 5 has hardware enc/decryption. Good luck!
Depends mainly how many videos you plan on hosting, storage space is the biggest issue.
I've self-hosted a 5€ Peertube instance before, no problems. Expanding the storage would be rather cheap but I never hit the 500GB VPS limit before I got bored of the whole thing and shut it down.
I think there should be options, included for open source. I know there's different architectures but look at ARM devices, a lot of software is compiled for that architecture too. I'd much rather sacrifice a big software catalogue for more free and secure solutions. More software would be available as time go by.
In one way I already do, running a custom android ROM with no Google services, with no Google Play there's a lot of software I miss out on. I'm perfectly happy with that.
I've used it to encrypt both Pi4's and 5's. I think it's most compatible with Raspberry Pi OS (Bookworm), used it on both Lite and Desktop editions. Remember to use non-AES encryption since only the 5 has hardware enc/decryption. Good luck!