Do AppArmor and Flatpak have any weird interactions?

I'm trying to generate AppArmor policies to secure my "major/internet-facing" programs.
Most of those programs are Flatpaks.
Flatpaks already have their own sandboxing mechanism, which uses bwrap and XDG portals.
Does AppArmor have any weird interactions with Flatpak, e. g. blocking too much, or blocking too little, or being unable to block anything without rendering the whole program unusable?