That looks like it’s meant to be stopped on a flash drive for quick tinkering, so fat32 would probably be the way to go.
Having said that I’d rather recommend tinyCore for that purpose instead personally. I’d also really like to point out neither that or porteus seem to be made for general use. If you are wanting a full desktop or laptop install they are both going to be absolutely terrible for that purpose
With just 30 gigs even Debian with xfce would probably take half that. I’d definitely agree with a second hard drive a 500 gig ssd is almost $50 these days
This won’t affect fedora. Fedora is upstream just like centos stream, and nothing they’re currently doing changes those projects. Besides possibly making people more hesitant to bother with rpm packages on GitHub at least
In this study, Rosenberg and her colleagues looked for drugs that could prevent or slow down E. coli bacteria from developing resistance to two antibiotics when exposed to a third antibiotic, ciprofloxacin (cipro), the second most prescribed antibiotic in the U.S. and one associated with high bacterial resistance rates.
The resistance is caused by new gene mutations that occur in the bacteria during infection. The drug DEQ reduces the speed at which new mutations are formed in bacteria, the team finds.
Previous work from the Rosenberg lab had shown that bacterial cultures in the lab exposed to cipro turn up mutation rate. They found a mutational “program” that is switched on by bacterial stress responses. Stress responses are genetic programs that instruct cells to increase production of protective molecules during stress, including stress from low concentrations of cipro. Low concentrations occur at the beginning and end of antibiotic therapies and if doses are missed.
The same stress responses also increase the ability to make genetic mutations, the Rosenberg group, then many other labs, have shown. Some of the mutations can confer resistance to cipro, while other mutations can allow resistance to antibiotics not yet encountered. Mutation-generating processes that are turned on by stress responses are called stress-induced mutation mechanisms.
Bacteria with antibiotic resistance mutations can then sustain an infection in the presence of cipro. This study is the first to show that in animal infections treated with cipro, the bacteria activate a known stress-induced genetic mutational process. Cipro resistance occurs mostly by the bacteria developing new mutations, both clinically and in the laboratory, rather than by acquiring genes that confer antibiotic resistance from other bacteria.
Looking to prevent the development of antibiotic resistance, the researchers screened 1,120 drugs approved for human use for their ability to dial down the master bacterial stress response, which they showed counters the emergence of resistance mutations. In addition, and counterintuitively, they wanted “stealth” drugs that would not slow bacterial proliferation, which would confer a growth advantage to any bacterial mutants that resist the mutation-slowing drug itself.
That is, drugs that are not antibiotics themselves.
“We found that DEQ fulfilled both requirements. Given together with cipro, DEQ reduced the development of mutations that confer antibiotic resistance, both in laboratory cultures and in animal models of infection, and bacteria did not develop resistance to DEQ,” said first author Yin Zhai, a postdoctoral associate in the Rosenberg lab. “In addition, we achieved this mutation-slowing effect at low DEQ concentrations, which is promising for patients. Future clinical trials are needed to evaluate the ability of DEQ to decelerate bacterial antibiotic resistance in patients.”
This feels like the reviewers expected Debian to create their own desktop environment between releases or something. The point of Debian has always been a stable experience, not to be flashy.
!lemmy_support@lemmy.ml Might be worth asking on the support page if that would be possible. This community has the most subscribers by a decent amount so I'd think it would be good to try to stay set up on here.
Have you tried another browser like Firefox? I’ve never had copy paste issues between any of my apps