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  • Actual article. https://www.cell.com/cell/fulltext/S0092-8674(25)00210-7

    Essentially they find that interleukin-6 (IL-6) a well-known inflammatory signal is important to neuronal lymphatics which are key to brain waste removal. Frankly, not too surprising imo but they do drill it down very well to what cells are effectors/affected. They use a drug, PLX5622, to inhibit this IL-6 activity and see significant improvement to mice where neuronal inflammation had been induced, genetically or surgically.

    I'm very sleepy so didn't read into any side-effects they notice or discuss as possibilities.

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  • Tell me honestly if you were added to such a chat would you think it serious or some sort of military larp chat?

    Then tell me you'd be able to contact the houthis in less than 2h much less being trusted about it or any sort of secretive about it?

  • That allows visualization of PCRed product, which is a far cry from whole genome sequencing. You can visualize a target at a time with no sequence info. Using it for sequences would be extremely tedious and require a lot of runs.

  • The bigger question rather than letting them step into that spot is whether it means we'll let them take Taiwan and other contested islands in the Pacific without a struggle. I think they'll be allowed because there isn't another option while Republicans remain in power in the US.

  • Big reason behind how Walmart destroys communities. All the mom&pop stores can't compete and start going out of business. They either have to move or work at Walmart. Walmart pays shit so even if you wanted to you can't afford any remaining mom&pop. Then once you can't even buy at Walmart or try and fight for better pay and conditions, they just fucking leave and everyone is out of work and there's no stores to take on employees or customers.

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  • Not just presidential matters. Local and state are much less fucked with. A 3rd party in first past the post just creates a split of neolib/socialists while the fascists remain united. Division in the American system is just a way to have the other party win. Republicans allowed the Tea party because that is what they wanted as well. Neolibs won't allow a split progressive/socialist with the exception of Bernie (because how do you fuck with Vermont).

  • Is this an actual firing or a thing like the nlrb or whistleblower where it is illegal and gets reversed. I remember Biden not being able to fire R commissioners from their positions being a reason for certain things not getting done.

  • There were some hopeful years during reconstruction, lots of black officials before Jim crow and kkk. It didn't last because presidents after Lincoln abdicated their responsibility of educating the south and preventing voter/elected official intimidation.

  • I think it's very telling that mamdami's money comes from 16,000 individual donors while Cuomos comes from less than 3,000 individuals. Cuomo still has name recognition and frankly most people don't care as shown by repeated election of moderate Dems even in "safe" democratic areas.

  • People are dumb, especially when lied to 24/7.

    The average Russian probably still thinks that Ukraine is Nazis and that they are winning. The average Chinese doesn't know about Tiananmen square students protest or the brutal suppression much less Uyghurs genocide. Name a country and there's something along those lines ongoing or at least in recent history. The far-right in Europe is doing much like America was just 10-20y ago other places are already ahead into their authoritarian phase.

  • The bigger effects will take years if not decades. Who is going to go into government work when they start hiring again? The salary doesn't beat industry so the primary draw was always stability. Doge has taken that away and it'll never come back if Rs and "moderate" Dems remain anywhere close to power.