From personal use, I can tell you that the featureset is just not there. You can't even sort by followed accounts only, or get chronological updates. It's a hot turd sandwich.
But just as a side note, a user can block an entire instance as well, at least on Mastodon. I haven't checked for that functionality on Lemmy. That's not defederation, but it prevents you from seeing things you don't want to at the user level.
There's a contradiction here. The Supreme Court ruled that Speech can't be compelled, not that you could bar certain people from a business. You could decline to decorate a cake with "MAGA", but not decline to sell a cake to a Republican, for example. What those signs are promoting is still illegal.
I had that exact conversation at work a few days ago. Someone was insisting that Spaniards are Latino, so I asked them if Spain is in Latin America or Europe. That was the key to them eventually figuring it out.
That’s an exercise in futility. If Lemmy takes off like Mastodon/Pleroma/Misskey/etc then you would spend your time trying to create accounts on hundreds of Lemmys, some of which will be private or invite only meaning you can’t. Plus, anyone on Mastodon etc. can comment on Lemmy posts. It’s not a task you can complete.
If not for gaming, I would run Linux. Linux on gaming just isn't on par yet.