The 16th Century Crisis was across Europe and that last link centers around the UK in the end in the English Civil War. It's a whole thing that led up to it.
Yep, looks like it is used for that too. It is used to treat a lot of different things but most of it is currently under trials. Fingers crossed they pass
It works for about half the people that try it from what I have read. I got lucky. I never had luck with anything else. Mine likely stems from mild hereditary ocd FWIW. It's one of those problems I never thought a pill would fix, let alone a supplement lol.