Scientists at Harvard University claim to have come excitingly close to finding the proverbial Fountain of Youth. According to a recent publication in the scientific journal Aging, the team has identified six chemical concoctions that have the ability to reverse the aging process in both human and mice skin cells.
Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study, has hailed this as a "breakthrough" and sees it as a step towards "affordable whole-body rejuvenation."
Dr. Sinclair has even suggested that human trials could commence within the next year. This prediction has caught the attention of prominent figures, such as tech mogul Elon Musk. He responded to the news with curiosity asking, "Ok, so what exactly is it?"
How to create a Fountain of Youth pill
The researchers utilized high-throughput cell-based assays to distinguish young cells from their older, senescent counterparts. These senescent cells are cells that have stopped multiplying, a characteristic hallmark of aging.
Through high-throughput screening, the team was able to rapidly test thousands to millions of samples for biological activity at the model organism, cellular, pathway, or molecular level.
The specific markers used for aging included transcription-based aging clocks and real-time nucleocytoplasmic protein compartmentalisation (NCC) assay. NCC is a vital function in cells, including stem cells, bone cells, and muscle cells.
Six chemical cocktails for anti-aging
This comprehensive approach culminated in the identification of six chemical mixtures that, according to the press release, "restored NCC and genome-wide transcript profiles to youthful states and reversed transcriptomic age [biological age] in less than a week."
Upon testing these cocktails on mice and human cells, the results suggested a de-aging effect for all six combinations.
"The effect of this four-day treatment is comparable to the total change seen after a year of a regenerative treatment described in a landmark study from 2019, which also focused on restoring epigenetic information," said the researchers. Researchers evaluated age changes using rodent and human transcriptomic clocks, which predict biological age using gene expression data.
"This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases," said Dr. Sinclair.
Some experts are skeptical
However, other biologists have met this enthusiastic claim with skepticism. Matt Kaeberlein, a biogerontologist, offered cautious praise. He says that the innovative screening method could one day lead to significant discoveries. However, he also noted that the study is preliminary.
Kaeberlein suggested that the team should have validated at least one of the concoctions in an animal model. He believes they also should have shown improvements in age-related health metrics or lifespan before making these claims about effects on biological aging.
Dr. Charles Brenner, a metabolism researcher, raised concerns about three compounds in the study. The first is CHIR99021, which blocks glycogen formation activated during sleep to store energy. Next is tranylcypromine, an antidepressant. Finally,valproic acid, used to treat bipolar disorder but can potentially harm the liver.
The study did not mention these potential risks. Brenner warned, "These are generally not safe alone or in a combination."
Moreover, Brenner criticized the study for not using single-cell sequencing to evaluate cell identity. He pointed out that researchers initially reported these cocktails in 2013, suggesting that the compounds are not new discoveries. "Getting these readouts on cells is not a groundbreaking study on reversal of aging," said Brenner.
Amidst this range of responses, it's clear that we need to conduct further research and careful examination before we can proclaim the arrival of a true Fountain of Youth pill.
Let them require it. Search engines like DDG should really begin maintaining their own index, and they should exclude sites that use the tech from the index.
I can also see Apple taking a stand against this. They have a competing (and much more reasonable) implementation that respects user privacy.
I personally find the Apple One family plan to be an awesome deal. Music/Arcade/TV/Fitness/News. Out of all of these, news is pretty “meh”, though you do get access to popular magazines/newspapers. Everything else is great.
I am not an all Apple guy, since I am a PC gamer, but I use Apple products most of the time.
On Arch, upgrading is pretty simple. The only extra step is you need a hook to run mkinitcpio, but that script is on the wiki and you never need to touch it again once set up. From that point onward you just upgrade the driver via pacman.
Don’t get me wrong, I do not like the fact NVIDIA’s drivers aren’t open source and their linux offerings aren’t the greatest, but your issue appears to be due to the way your distro handles the driver.
Correct. Valve could have let them release it and let Nintendo go through the DMCA process. As long as Valve follows the process, they would not be the subject of any litigation.
Did you read the article? This is Valve’s doing, not Nintendo. The keys weren’t even in question. Valve is requiring the Dolphin devs to get permission from Nintendo, something that will never happen.
I have had no issues. Even if they did end up successfully blocking (not likely) the videos are accessible via 3rd party sites/clients. I don’t see Google ever being able to successfully block users without adding a login requirement, and even then…
I have never seen a cheaper AirBnB offering. Where are these cheap offerings you speak of.
The last time I went to Ottawa, AirBnB was twice as much as the Marriott, plus you had to clean or pay a cleaning fee. Neither of those are things at a hotel.
I actually owned the first one he mentioned and it died after a few months of 9-5 usage.
I had tons of issues with the cheap ones sold by 3rd party resellers, mostly because they are cheap chinese crap with bottom of the barrel components inside. However, what the author fails to pay attention to is that Macs have Thunderbolt 4 ports. Yes, Thunderbolt is compatible with USB-C, but you are adding a layer of complexity into the mix. Instead I recommend getting a native Thunderbolt dock.
I eventually paid a premium for a native Thunderbolt 4 dock and have had zero issues since.
I made a lot of money from GME. I bought a bunch of shares early on for $10-$50 and sold the morning when Robinhood yanked the buy button. However, most WSB plays are money losers.
Damn, Mr. Musk could have made more money betting on stocks mentioned in r/wallstreetbets, and they ALWAYS lose money. Dude seriously needs to have twitter do the opposite of what he thinks.
I have never seen a billionaire try to go from billions to zero so hard in my life. It is like he is showing the U.S. government why billionaires shouldn’t exist.
Is there a fund that lets me do long term shorts on rich people?
Scientists at Harvard University claim to have come excitingly close to finding the proverbial Fountain of Youth. According to a recent publication in the scientific journal Aging, the team has identified six chemical concoctions that have the ability to reverse the aging process in both human and mice skin cells.
Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study, has hailed this as a "breakthrough" and sees it as a step towards "affordable whole-body rejuvenation."
Dr. Sinclair has even suggested that human trials could commence within the next year. This prediction has caught the attention of prominent figures, such as tech mogul Elon Musk. He responded to the news with curiosity asking, "Ok, so what exactly is it?"
How to create a Fountain of Youth pill
The researchers utilized high-throughput cell-based assays to distinguish young cells from their older, senescent counterparts. These senescent cells are cells that have stopped multiplying, a characteristic hallmark of aging.
Through high-throughput screening, the team was able to rapidly test thousands to millions of samples for biological activity at the model organism, cellular, pathway, or molecular level.
The specific markers used for aging included transcription-based aging clocks and real-time nucleocytoplasmic protein compartmentalisation (NCC) assay. NCC is a vital function in cells, including stem cells, bone cells, and muscle cells.
Six chemical cocktails for anti-aging
This comprehensive approach culminated in the identification of six chemical mixtures that, according to the press release, "restored NCC and genome-wide transcript profiles to youthful states and reversed transcriptomic age [biological age] in less than a week."
Upon testing these cocktails on mice and human cells, the results suggested a de-aging effect for all six combinations.
"The effect of this four-day treatment is comparable to the total change seen after a year of a regenerative treatment described in a landmark study from 2019, which also focused on restoring epigenetic information," said the researchers. Researchers evaluated age changes using rodent and human transcriptomic clocks, which predict biological age using gene expression data.
"This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases," said Dr. Sinclair.
Some experts are skeptical
However, other biologists have met this enthusiastic claim with skepticism. Matt Kaeberlein, a biogerontologist, offered cautious praise. He says that the innovative screening method could one day lead to significant discoveries. However, he also noted that the study is preliminary.
Kaeberlein suggested that the team should have validated at least one of the concoctions in an animal model. He believes they also should have shown improvements in age-related health metrics or lifespan before making these claims about effects on biological aging.
Dr. Charles Brenner, a metabolism researcher, raised concerns about three compounds in the study. The first is CHIR99021, which blocks glycogen formation activated during sleep to store energy. Next is tranylcypromine, an antidepressant. Finally,valproic acid, used to treat bipolar disorder but can potentially harm the liver.
The study did not mention these potential risks. Brenner warned, "These are generally not safe alone or in a combination."
Moreover, Brenner criticized the study for not using single-cell sequencing to evaluate cell identity. He pointed out that researchers initially reported these cocktails in 2013, suggesting that the compounds are not new discoveries. "Getting these readouts on cells is not a groundbreaking study on reversal of aging," said Brenner.
Amidst this range of responses, it's clear that we need to conduct further research and careful examination before we can proclaim the arrival of a true Fountain of Youth pill.