Update: IRS successfully launches their own free Direct File - now ALL of my fellow 'murcans are eligible for 2025
Ranvier @ Ranvier @sopuli.xyz Posts 9Comments 928Joined 2 yr. ago
Ranvier @ Ranvier @sopuli.xyz
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Thank you for clarifying those misconceptions about what recessive and dominant are getting at. A gene isn't really dominant or recessive. A phenotype (some trait in the organism like blue eyes or a certain disease) can be dominant or recessive though and results from changes in a gene. The same gene could have many different possible mutations, some with dominant effects, some with recessive effects, or some with no effects, depending on the change in the gene and the phenotype.
To go further on that, many recessive diseases are because just one functional copy of many genes are fine from your body's perspective. Many recessive diseases are due to loss of function of a gene or its protein product, a gene that for a variety of potential reasons no longer leads to a functional protein. Often your body can get by with just one working gene making protein, though both gene copies are generally always being transcribed and trying to be turned into functional protein.
One big exception to this is the x chromosome. Males only have one x and have a y instead of a second x. The y is very tiny and has very few genes compared to the x, quite different from other chromosome pairs which generally just have copies of all the same genes on each other. Early in embryo development for xx individuals, one of the x chromosomes is generally inactivated and not expressed very much, otherwise xx individuals would have double the gene products of all those different genes compared to males, which the body is not expecting for x genes like it does for all the other genes that have a second copy.
https://en.m.wikipedia.org/wiki/X-inactivation
If you go even further you also get into the idea of penetrance. A gene codes for a protein, but that protein doesn't exist in isolation, it interacts with lots of other proteins coded by other genes in the body, plus the environment. So for some genetic changes it might be a 100% chance at leading to a certain phenotype (like a disease or a specific trait), or it could be less, like only 70% or 30% chance or something of someone with that change getting that trait, even if it's still "dominant" (meaning only one gene copy with that change is needed to express the trait).
Yes but saying it's psychological dependence only is is kind of misleading here. To most reading that would imply that's just addicting because they like doing it. A carrot does not contain a chemical that directly interacts with the learning and reinforcing centers of the brain, while cannabis does. Cannabis is directly addicting, carrots are not. I don't think it's a fair comparison.
Also it is your brain that kills you when you have alcohol withdrawal, it's why alcohol withdrawal is treated with central nervous system depressants. Opiod withdrawal generally won't be able to kill you but you certainly will feel like you want to die.
Be careful with your concept of physically versus psychologically addicted, it's not really a 100% seperatable dichotomy like that. Your brain is your brain after all, whether you decide to call something physical or psychological it's all happening inside the brain. I think because cannabis doesn't tend to have severe withdrawal effects (like alcohol withdrawal, which can kill you) people assume that means they're not dependent or that it doesn't have direct effects on the reward processing centers in the brain to reinforce its use again in the future. That's what distinguishes addictive drugs from things that are just generally pleasant so we want to do them again, they have a direct chemical interaction with the neural circuits that are supposed to be helping decide if a behavior should be done again or not. Kind of tipping the scales in their favor, making you want to do something again more so than just the pleasentness of the past experience alone would otherwise do. You're going to have an easier time quitting carrots than you will cannabis, even if you find them both equally pleasant in the moment.
Don't get me wrong though, cannabis is waaaay less addictive than things like nicotine or alcohol, and has far less harmful effects than those. I think there is a tendency (especially with things like DARE lying about drug dangers when people were younger) to over correct and say things like it's a miracle drug that's non addicting and can never harm you and can fix everything wrong in your life! I'm for recreational cannabis legalization, but people should understand it's actual risks, even though they are much less than other recreational drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069146/
The cumulative probability estimate of transition to dependence was 67.5% for nicotine users, 22.7% for alcohol users, 20.9% for cocaine users, and 8.9% for cannabis users. Half of the cases of dependence on nicotine, alcohol, cannabis and cocaine were observed approximately 27, 13, 5 and 4 years after use onset, respectively.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605022/#ref4
Cannabis-derived psychoactive compounds such as Δ9-tetrahydrocannabinol and synthetic cannabinoids directly interact with the reward system and thereby have addictive properties. Cannabinoids induce their reinforcing properties by an increase in tonic dopamine levels through a cannabinoid type 1 (CB1) receptor–dependent mechanism within the ventral tegmental area. Cues that are conditioned to cannabis smoking can induce drug-seeking responses (ie, craving) by eliciting phasic dopamine events.
Texas doctor who said nine-year-olds can safely give birth appointed to maternal mortality committee
Jump
What is wrong with people? Anyways, here's the facts:
https://pubmed.ncbi.nlm.nih.gov/35675595/
Compared with deliveries to patients aged 20-54 years, deliveries to patients aged 11-14 years were associated with increased risk for severe maternal morbidity (aOR 1.73, 95% CI 1.49-2.00), hypertensive disorders of pregnancy (aOR 1.79, 95% CI 1.71-1.88), and postpartum hemorrhage (aOR 1.37, 95% CI 1.27-1.49).
I can't even find data for kids as young as 9, because it's such a rare and obviously bad situation.
I know you're being sarcastic. The funny thing is though, these aren't even like climate change models. This is just based on the fact that the Atlantic ocean is much warmer right now than it usually is this time of year, which is most likely going to lead to more hurricanes this year. That energy has to go somewhere eventually. The Ocean right now in mid May is as warm is at usually is in Mid July in an already bad year, so this year could potentially be catastrophic.
This would make it far harder for the U.S. Department of Agriculture to add new items, or — as the Biden administration did in 2021 — to offer more support to, for example, buy more fruits and vegetables.
Republican party platform: people in poverty have far too much access to vegetables! This must be capped.
First of all, video is inaccurate as you would have guessed:
If they really want a meet baby Olivia video, besides correcting its inaccuracies, I would suggest we have a meet mother Dorota video. It would teach students about how mother Dorota could have had her life saved with an abortion, however laws and court rulings by men ensured doctors would go to jail if they didn't wait until she wasnt clearly in danger of losing her life before the abortion was performed. It turns out if you wait until someone's life is definitely in danger as most of these laws now require, well then their life is definitely in danger and they might still die at that point no matter what the doctors do. There's no magic point of, now the doctors know 100% you will die without the abortion and there's a 100% chance they can pull you back and you'll be fine.
We could also learn about the trauma of carrying a fetus all the way to term even though it has a horrific developmental malformation that means it will immediately die on delivery, or never even be able to make it all the way to term and most likely die in utero. And how these pregnancies often increase the risk of serious complications for the mother if they continue to be carried. Heck there's a lot we could teach about, I could go on.
Sympathizers? I mean they started the trump presidency by marching in the streets with torches and there's already been a Reichstag fire. Trump kept a collection of Hitler's speeches on his night stand and rips lines straight from it all the time. I think you can just call them Nazis.
It's part of the process. Now the request is before judges who will decide whether or not to issue the arrest warrants. For reference, when an ICC prosecutor asked for an arrest warrant for Vladmir Putin, it took a couple months for the judges to decide and then issue the warrant.
Yeah totally. And everyone will feel super satisfied for really sticking it to Biden for not providing enough Palestinian aid or pushing Israel hard enough in their opinion, while only holding back some weapons from Israel, and not doing a pointless veto of congressionally allocated funding that would be immediately over ridden by congress. And then when Trump is elected later this year.... Let's see here....
Oh yeah, withdrawing all aid from Palestine (like he did before), helping Israel to "finish the job" in the Gaza strip, and then strike some corrupt deals with Netanyahu and his son in law to divide up all this sweet recently vacated beach front property. And yes, this is the same son in law he put in charge of Israel Palestine peace "negotiations" during his term.
By all means vote for the most progressive politicians you can. But you have to grapple with the current reality of a first past the post voting system, and not voting at all is even more stupid.
I hate all this accelerationist nonsense. Let's sit out this election and have an authoritarian facist takeover! Surely this will help push the country to the left like we want.
Yeah but it wasn't just fundamentalist religious zealots. It was also a lot of corporations and capitalists determined to make a profit no matter what, even at the cost of great human suffering and they dragged over a bunch of indentured servants and slaves and oh wait I think this explains a lot about the US.
They are now legal to grow in many states. Unfortunately still not going to find it in a grocery store most likely. I grow my own in the backyard so I can have some at least part of the year. They're perennial, very easy to grow, and produce a ton of berries. Gooseberries were banned for similar reasons, but are now also legal in many states.
Yes I agree, but it doesn't just have to meet some of those criteria to get an injunction, it has to meet all those criteria, including likelihood of success. They can't just argue irreparable harm only if the judge thinks they're unlikely to succeed. The judge seems to agree with them in that section of the ruling that he thinks that the rule is likely unconstitutional. And conservative judges have been pretty hostile to the consumer financial protection bureau in general. I'm not holding my breath, at least not for this judge, but maybe ultimately on appeal the cfpb will still succeed in the end.
The legal standard for an injunction also includes a "likelihood of success on the merits." The judge agrees with the banks in his ruling that they are likely to succeed on the case. So unfortunately the injunction is a signal there is a good chance he rules in the banks favor ultimately. Though he spends a bunch of the ruling just talking about how he's mad this case was kicked back to him. He only spends like a page talking about if the legal standard for injunction has been met or not.
It's a little weird, here's an article that would describe the process of making some if you're curious:
https://www.masterclass.com/articles/how-to-make-easy-homemade-jelly-basic-jelly
I prefer jam in general, but a lot of people find this stuff easier to spread on a pb&j sandwich (like softer untoasted bread) or other uses where a thick texture would make jam more difficult to use but they still want the fruit goo (like filling a pastry with maybe). Usually we would use the word jam to mean like a chunkier fruit preserve, and jelly specifically refers to this stuff.
Infuriating thing was, this judge was clearly shopped for, but he kicked the case to the DC district Court instead of Texas. He himself even accused the banks of venue shopping in the ruling when he did so! Unfortunately the DC district court sent it right back and said he still had to take the case. He should have recused himself at that pont anyways given his stock holdings and things, but he now decides to reward the the banks for their venue shopping he's clearly aware of. Judiciary is rotten.
https://www.yahoo.com/news/texas-judge-moves-fee-case-232103686.html
The bill went along party lines out of committee, 11 Democrats in favor 10 Republicans against.
https://www.reuters.com/world/us/senate-panel-set-vote-us-supreme-court-ethics-reform-2023-07-20/
Dead due on arrival though, due to unanimous republican opposition in both the senate and house (controlled by Republicans). Even if you wanted to argue for Democrats overturning the filibuster or something, it still wouldn't solve the issue of the house. Anyways the point is, republicans are far more of a problem for judicial reform than your "moderate dems."
There's about 100,000 flights a day in the world. Until very recently Boeing was the largest provider of commercial aircraft, and it's still second largest next to airbus. It's basically a duopoly with those two manufacturers providing the vast majority of planes. Even with the small rate of accidents, with so many flights every day involving Boeing planes there's going to be a few.
Editors know anything relating to an airline accident and Boeing right now will get lots of clicks, they just throw that it's a Boeing aircraft in the headline, then bury relevant facts indicating there's really no way this could have anything to do with Boeing quality control in the article. And many of these are about events that happen from time to time anyways but wouldn't normally make any sort of splash in the international news media, so suddenly it feels like you're being bombarded with Boeing news. If the headline writer put GE or Rolls Royce airplane engine fire due to likely accidental bird collision, or Garuda Indonesia airline repair standards are subpar or something, it wouldn't get any clicks.
Only catch is Republicans probably launching some type of legal action to try and stop it.
https://www.nysscpa.org/news/publications/the-trusted-professional/article/13-republican-ags-seek-to-stop-irs-s-fre-direct-file-pilot-program-020224
No lawsuit launched yet to my knowledge, just sternly worded letters saying please stop helping taxpayers instead of letting predatory companies like Intuit fleece money off of them.
I would expect them to try something soon though with this announced.