No_Eponym @ No_Eponym @lemmy.ca

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Joined

2 yr. ago

To evaluate the impact of psilocybin on longevity in vivo, aged (19 month) female mice were treated with vehicle [vehicle is what the psilocybin was suspended in for injection] or psilocybin [actually vehicle + psilocybin] once/month for 10 months; mice were initially given a low-dose (5 mg/kg) for the first treatment followed monthly high-dose (15 mg/kg) treatment for a total of 10 treatments. We elected to utilize 19-month old mice, which is roughly equivalent to 60–65 human years, in order to evaluate its therapeutic potential as a clinically-relevant anti-aging intervention.

Within 30 min post-treatment, mice exhibited increased head-twitch response, which is a well-established behavioral indicator of hallucinogenic impacts of psilocybin in mice. Both psilocybin and vehicle groups exhibited some loss in body weight from the start to end of the treatment protocol, however weight loss was not significantly different in vehicle vs. psilocybin-treated mice. Notably, psilocybin treated mice demonstrated significantly higher survival (80%), compared to vehicle (50%).

Although not quantitatively measured, psilocybin-treated mice exhibited phenotypic improvements in overall fur quality, including hair growth and reductions in white hair compared to vehicle-treated mice.

In summary, we provide the first experimental evidence demonstrating that psilocybin treatment can enhance survival in aged mice.

So, caveats:

• This is the first study; while further studies may show a similar result, we won't know for sure until they are completed. This could be a fluke. This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
• This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
• Typical doses for psilocybin are 0.2–0.4 mg/kg in therapeutic settings, 4mg/kg for microdosing, to up to 20 mg/kg to be legitimately tripping; like the mice, if you use this regimen you will need to set aside a day to be tripping once a month, and after 10 months take a heroic dose and have a really big trip. Not impossible to arrange for many people, but this is not a regimen you can do while completely going about your regular day-to-day.

TLDR: Promising results in an under studies area. More studies are required to confirm results. Following this regimen will cause a non-trivial disruption in your monthly routine.

Meanwhile, wages have not kept up, largely to support/advantage/non-impact for those who bought in earlier. Boomers take advantage of low taxes, low-cost services, etc. driven by low wages.

Even with low interest rates, the size of the necessary downpayment is prohibitive and exposure to interest rate related shocks are much greater.

And everything else is much more expensive for an expensive house, including insurance, which is also getting harder to get and more expensive due to climate change.

Tl;DR: Younger generations are not getting housing because of older generations. We all know the answer to this question...

the internet was for porn

Why you think the net was born?

Not the mandatory volunteering to help plan, execute, and clean up after the optional mandatory after-work in-office no-alcohol team building event?

Unscaled fines punish people for being poor, because the punishment is a larger percentage of their disposable income.

Why should a poor person pay a fine of 30% of their monthly take home, while a rich enough person pays 5% (or less?) of their take home for the same infraction.

The only fair solution is for the fine to amount to an equal percent of your take home pay. Then it is the same punishment for everyone.

I mean, he is actively cutting the SEC for his own scamy benefit, he is tanking the dollar, he is ruining the economy, he is defenestrating the rule of law and due process, and he is doing his best to overthrow the federal reserve. Also, Republicans kind of hate a lot of the companies in the Mag 7 and are all on board for antitrust suits against woke oligopolies. If equities are investments you hold for the long haul, regardless of how the US has done in the past, how can you see current actions working out well for investment in the future?

Get off the American meme stock market rocket, chances are growing it will do a SpaceX to your investments.

University budgets are hard, even in a petro state. Gotta get that international student tuition at 10x the rate of domestic tuition to make sure they can pay for such things as are fundamental to the essential function of scholarship and higher learning:

• the university President's 2nd private jet
• lobbyists to help protect academic journals that publish research paid for by public dollars for enormous profit
• many consultants that do important things like rebrand the university logo every years

/sarcasm

That was when they suspended the Constitution. They said it would be temporary. There wasn't even any rioting in the streets. People stayed home at night, watching television, looking for some direction. There wasn't even an enemy you could put your finger on.

wizard math

service guarantees citizenship

Do these designs have any impact on emergency vehicles? Or do they cost more to put in than a regular road? Do they make driving less efficient and cause more emissions? Can they be ignored like lights or stop signs?

I feel like speed cameras might be a better solution than speed bumps or other road barriers. Penalize the bad drivers up to and including taking away their driver's license if they can't comply with the rules, allow emergency vehicles to somewhat the need to do, and collect some revenue to offset the cost of enforcement of safety.

Traffic sign/signal camera are a good idea too. If you can't/won't follow the rules of the road, I think you should pay fines and eventually have your license removed. Cameras are a far more effective way to do that than officers.

Also

[Review] by james schreiber

but also

...since his father left me...

the Julius Caesar of our time—Donald Trump

Biiiiig doubt right off the bat, but I'll keep reading.

We can’t stop people free-riding, it’s part of our nature, the incurable syndrome… Free riders are among us ... if we accept that we all have this ancient flaw... we can design policies around that and change our societies for the better.

Right, ok, I guess that makes sense. How do we fix it then?

Self-knowledge: ...appearing trustworthy but being selfish can be more beneficial to the individual. We need to recognise that and make a moral choice about whether we try to use people or to work with them.

Ok, sure, for the less-selfish folks who have the capacity for self-awareness. But the more selfish folks already know this because they are exploiting it.

Education: We must teach people to think ethically for themselves, and to give them the tools to do so.

Hmm, big doubt. We've been trying to do this for ages in many societies. Not only has it not been a panacea, the selfish often hijack the education systems themselves.

Policy: Goodman believes that exposing free-riders is more beneficial than punishment.... suggesting that journalistic work exposing exploitation can be as effective... as criminal punishment.

Ok, you lost me. Maybe the book is better, but this is garbage. I don't care about changing behaviour, I want to stop the bleeding. Criminal punishment for the criminally sociopathic! This guy and Susan Collins can keep eachother company...

So if they plan to make B.C. "tax-free," will they work for free too? 'Cause guess where the money to pay MLAs comes from...

They might still get you on skin colour, ethno-linguistic origin of name, left-wing political affiliations, religious affiliations (or lack thereof), type of employment or specific employer, perceived accent, or a boarder agent just having a very bad or a very good day.