Never Forget
Instigate @ Instigate @aussie.zone Posts 3Comments 334Joined 2 yr. ago
Instigate @ Instigate @aussie.zone
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334
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2 yr. ago
Prion diseases are fatal infectious neurodegenerative disorders and prototypic conformational diseases, caused by the conformational conversion of the normal cellular prion protein (PrPC) into the pathological PrPSc isoform.
The immune system does not develop a bona fide immune response against prion infection, as PrPC and PrPSc share an identical protein primary structure, and prions seem not to represent a trigger for immune responses. This asks for alternative vaccine strategies, which focus on PrPC-directed self-antibodies or exposure of disease-specific structures and epitopes. Several groups have established a proof-of-concept that such vaccine candidates can induce some levels of protective immunity in cervid and rodent models without inducing unwanted side effects. This review will highlight the most recent developments and discuss progress and challenges remaining.
Have a read through the full article and sources below and you can take a look at some novel approaches being evaluated at the moment:
Plenty of places to eat crocodile in Australia too, particularly up North in Queensland or the Northern Territory, but it’s also available throughout the mainland. We even have croc farms - mostly for the leather - but the good quality meat is sold on for people to eat too. It’s pretty gamey meat, and tastes a bit like a chicken-fish. Aboriginal peoples across some Countries in Australia have special licence (by way of their heritage) to still hunt croc for their pelts and meat, and to maintain their numbers as a part of practicing their cultural heritage.
Yeah, I’d almost say it’s an essential purchase. I buy a fair few online titles and I’ve found my 128Gb SD to be a bit lacking. I’m considering upgrading to a 256Gb or 512Gb but they’re still too expensive at high transfer rates.
If you have to choose between capacity and transfer rate for an SD card for a Switch, go for transfer. I had an old slow card and that was abhorrent for load times and stuttering on games that were stored there.
His work is important to study from an historical perspective in order to see how psychology grew into what it is today, in the same way that it’s important that we learn about outdated concepts like tabula rasa and phrenology in order to better understand what is correct. The fact that he applied so much of his own subjective thoughts to his brand of psychology shows us how we, as potential future psychologists, also have the same capacity to search for confirmatory evidence and eschew disproving evidence in search of a theory. He’s a great example of what not to do when it comes to psychology.
I recently bought an adjustable clip to clip the Switch (sans joycons) to my Pro Controller and it’s super comfy for long periods of gaming. I’ve also seen people use 3rd party joycons that are shaped more like the Pro Controller handles which seem comfy too.
You’re right, the base Switch isn’t all that comfy for long periods of play, but there are both ways around that and it can also be played docked, which I think are redeeming features.
Further to this - it doesn’t download cart data to the Switch/SD card, but it does store save data, update data and DLC data on the Switch/SD card. So while BOTW may not download its whole 10Gb onto the Switch, you may end up with a few Gb in other data that’s locally stored.
The Switch design is an evolution of the Wii U controller, which itself was evolved from the the lower screen design of the DS, which itself was modelled on the old Vertical Multi Screen Game and Watches from the 1980s.
Have a look through all of Nintendo’s consoles and you’ll see the lines of inspiration drawn from generation to generation.
Mathematics is the only true science.
Physics is applied mathematics.
Chemistry is applied physics.
Biology is applied chemistry.
Psychology is applied biology.
Sociology is applied psychology.
Et al.
Craaaaaaab people,
Craaaaaaab people,
Taste like crab,
Talk like people
I’m often torn when talking about how to vote in US elections because you guys have to balance ideology with the need to be pragmatic far more due to the First Past the Post (FPTP) voting system. The only way that Democrats get a serious signal that they need to move left is by voting for far-left candidates, even those who aren’t on the ballot, but that runs the risk of handing the election to the Republicans.
Y’all seriously need some Ranked Choice (RC) voting. I have never once voted for a major party number 1 in any election I’ve participated in, and that’s never caused my vote to be ‘wasted’ like it can be under FPTP. Mandatory voting would really help too - it would expose the fact that Republicans only make up around 30% of all people and they’d never be able to govern outside a coalition ever again.
I firmly believe that if the US got rid of the primary elections and implemented both RC and mandatory voting, we’d be nearing the end of Bernie Sanders’ second term right now.
When Mr Lehrmann faced criminal trial for sexual assault in the ACT Supreme Court in 2022, he was provided with material that both parties could have used to mount their arguments.
This material was not meant to be made public, because it was never used in open court. This is known as the Hearne v Street obligation.
However, it aired on the Seven Network's exclusive Spotlight interview with Mr Lehrmann.
Mr Lehrmann repeatedly gave evidence in his defamation case, on at least four occasions, that he did not provide Seven with anything more than an interview.
Justice Lee said he was "satisfied" Mr Lehrmann made false representations to the court about at least part of this material.
"In the absence of any other explanation, the inescapable conclusion is that Mr Lehrmann provided access to Mr Llewellyn to the relevant photographs," he said.
While conceding he was "not some sort of roving law enforcement official", Justice Lee left the door open for another court to pursue the alleged breach of the Hearne v Street obligation.
There seems to be a potential new path of legal inquiry here aside from any potential new case by the ACT. Punishments aren’t severe, but he could basically be found in contempt of court and fined or (unlikely) imprisoned.
Definitely agree with a lot of the listed games but wanted to add some I haven’t seen yet:
- Monster Hunter: Rise. The Monster Hunter series’ most recent main series instalment sees you playing as a Hunter of massive creatures, carving them up and using the parts to craft stronger and better equipment. Multiplayer only available with multiple switches, but is still a very rewarding solo game.
- Cadence of Hyrule. A Zelda and Crypt of the NecroDancer mashup that sees you play as Link or Zelda in a musical world where everything moves at the speed of the beat of the music. Very novel and interesting game, but relatively short.
- Pokémon Mystery Dungeon: Rescue Team DX. This is a true roguelike and a remake of the first game in the offshoot Pokémon Mystery Dungeon series made by the same creators of the Shiren the Wanderer series. Gameplay is turn-based and grid-based, with randomly generated dungeons for you to conquer, and you play as a human who’s been turned into Pokémon alongside many others you can befriend.
The way I like to think about it is that social media has acted as a magnifying lens for many aspects of social interaction, for both positive and negative. The positives include greater sharing of knowledge, better lines of communication with relatives, easier capacity to organise and protest… but the negatives include what you’ve described: bigotry and social division, commercialisation, and exploitation of the dopamine-reward system for profit gain among many others. It’s brought together some amazing people but has rewarded some abhorrent behaviour. Social media has both intensified and distorted our social interactions.
I think he’d feel this similarly devalues it.
I respect Watterson too much to assume his stance.
Well… which is it? Do you respect him too much to assume his stance or are you assuming he’d feel this similarly devalues it?
Particularly nuclear fusion, which doesn’t generate long-lived radioactive isotopes as byproducts of energy production. Nuclear fission still has a place to be sure, but once we crack the dilemmas with fusion all bets are off when it comes to generating huge amounts of clean energy.
Seconded. Dude is absolutely one of our worst exports; not that far behind Rupert Murdoch.
We (Australia) need to withhold all forms of support from Israel until a thorough investigation takes place. If we stopped funding UNRWA because of allegations from Israel (that have turned out to be specious at best) that UNRWA staff were involved in October 7, then we can stop funding the Israeli government over this. I welcome the relatively strong words from Albo here, but he should have stated that Australia is demanding a ceasefire, not just renewing calls for one. Another war crime has been committed, and we can’t keep using flowery language around this.
This becomes truer with each passing day, and is a big factor as to why young people job hop so often - if their talents aren’t being adequately remunerated the only redress they have is to find a better job with better pay. It seems strange to me that experience within a company and your tenure of service are no longer being rewarded, but perhaps that’s just another expression of how commodified our labour has become.
There are two ways to think about rights: there are legal rights and then there are human rights. Legal rights are conferred by some piece of legal document (legislation, constitution or common law) that a person is able to seek legal redress if their right has been revoked or diminished. Then there are human rights - what we as individual humans believe that each humans should expect as a basic right. The two are not always aligned, predominately because human rights vary greatly from one person’s interpretation to the next.
I think what the company is probably (accurately) arguing is that there is no legal right to swim in the UK, as no specific document states this with any specificity, so the complainant isn’t due compensation or redress of behaviour under the law. This is what the courts will examine as they are the interpreters of law but not the creators of law.
Now, does she have a human right to swim there free of sewage? I damn well think so, and I don’t think that would be a controversial opinion either. The problem is that what we think the law should be and what it is are often different, because legislation can’t represent every view simultaneously. There’s no law that could be drafted that makes forced birthers and pro choice people agree - someone will always lose out.
All of this is to say that while fighting this in court is a shitty thing to do (pun very much intended), it makes sense based upon the way our legal system is set up. There is no incentive for private business to respect rights that are not legally conferred, but there is a financial incentive to do the ‘cheaper and technically legal’ thing. Until we overhaul our legal systems to be inherently protective rather than inherently exploitative, this behaviour will continue.
That’s… not how statistics work there, friend. If there’s a 10% chance of something happening per person and I have ten people in a room, that doesn’t guarantee that one of them will have the thing happen. In fact, my sample could have 10/10 happenings or absolutely nothing happen and the statistic value would stay the same, because it’s an average of the entire population.
Trying to apply anecdotal evidence to statistics and then calling the statistic false when it doesn’t align with your anecdote is kinda doing things arse-backwards.