From the abstract: "By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. "
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug development2, highlighting an urgent need to better understand disease mechanisms. Here we show how functional genomics could address this challenge. By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. Genes regulated by ETS2 were prominently expressed in diseased tissues and more enriched for inflammatory bowel disease GWAS hits than most previously described pathways. Overexpressing ETS2 in resting macrophages reproduced the inflammatory state observed in chr21q22-associated diseases, with upregulation of multiple drug targets, including TNF and IL-23. Using a database of cellular signatures7, we identified drugs that might modulate this pathway and validated the potent anti-inflammatory activity of one class of small molecules in vitro and ex vivo. Together, this illustrates the power of functional genomics, applied directly in primary human cells, to identify immune-mediated disease mechanisms and potential therapeutic opportunities.
https://foodstruct.com/food/cheesecake
5.5g per 100g serving, and it's a pretty balanced protein. The fat combined with carbs makes it relatively low glycemic index at 50. Also at about 5:1 carbs to protein it's pretty close to the 4:1 ratio recommended for endurance athletes by Edmund R. Burke, PhD. One of my professors would say, "There are no junk foods only junk diets."
Both Georgia the country, and Georgia the state of the United States are located on planet Earth. I wanted to make clarification to save people trouble. Is that not ok, with you?
Sheldon Adelson's widow. yeah, this all makes way too much sense. Presidential Medal of Freedom recipient in 2018, from #45. The wikipedia pic of her shows #45 solemnly placing the medal around her neck.
“The fact, I think, that he has no remorse – quite the opposite, he continues to deny his guilt – is going to hurt him at sentencing,” said Jeffrey Cohen, an associate professor at Boston College Law School and a former federal prosecutor in Massachusetts. “It’s one of the things that the judge can really point to that everybody is aware of — that he just denies this — and can use that as a strong basis for his sentence.”
A little chortle now and then. Keeps things from getting to 'heavy'.